Histidine

Histidine (symbol His or H) is an essential amino acid. It is used in the biosynthesis of proteins. It is a positively charged amino acid.

Originally it was thought essential only for infants. It has now been shown to be essential for adults also.^[1] It is encoded by the codons CAU and CAC.

Histidine was first isolated by Albrecht Kossel and Sven Gustaf Hedin in 1896.^[2] It is also a precursor to histamine, a vital inflammatory agent in immune responses.

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↑ Kopple J.D. & Swendseid M.E. 1975. Evidence that histidine is an essential amino acid in normal and chronically uremic man. Journal of Clinical Investigation. 55 (5): 881–91. doi:10.1172/JCI108016. PMC 301830. PMID 1123426
↑ Vickery, Hubert Bradford; Leavenworth, Charles S. (1928-08-01). "On the Separation of Histidine and Arginine" (PDF). Journal of Biological Chemistry. 78 (3): 627–635. doi:10.1016/S0021-9258(18)83967-9. ISSN 0021-9258

[1] Kopple J.D. & Swendseid M.E. 1975. Evidence that histidine is an essential amino acid in normal and chronically uremic man. Journal of Clinical Investigation. 55 (5): 881–91. doi:10.1172/JCI108016. PMC 301830. PMID 1123426

[2] Vickery, Hubert Bradford; Leavenworth, Charles S. (1928-08-01). "On the Separation of Histidine and Arginine" (PDF). Journal of Biological Chemistry. 78 (3): 627–635. doi:10.1016/S0021-9258(18)83967-9. ISSN 0021-9258

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