Thiamine

Thiamine
	Skeletal formula and ball-and-stick model of the cation in thiamine
Clinical data
Pronunciation	/ˈθaɪ.əmɪn/ THY-ə-min
Synonyms	Vitamin B1, aneurine, thiamin
AHFS/Drugs.com	Monograph
License data	US DailyMed: Thiamine; US FDA: Thiamine;
Routes of; administration	by mouth, IV, IM
Drug class	vitamin
ATC code	cation: A11DA01 (WHO) ;
Legal status
Legal status	US: OTC ;
Pharmacokinetic data
Bioavailability	3.7% to 5.3% [medical citation needed]
Elimination half-life	1.8d[better source needed]
Identifiers
	IUPAC name 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;
CAS Number	cation: 70-16-6 ; 67-03-8 (Cl-.HCl); Cl- salt: 59-43-8 ;
PubChem CID	cation: 1130;
PubChem SID	Cl- salt: 6042;
DrugBank	cation: DB00152;
ChemSpider	cation: 1098;
UNII	cation: 4ABT0J945J; Cl- salt: X66NSO3N35 ;
KEGG	cation: C00378;
ChEBI	cation: CHEBI:18385;
ChEMBL	cation: ChEMBL1547;
Chemical and physical data
Formula	C12H17N4OS+
Molar mass	265.36 g·mol−1
3D model (JSmol)	cation: Interactive image;
	SMILES cation: Cc2ncc(C[n+]1csc(CCO)c1C)c(N)n2;
	InChI cation: InChI=1S/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1 ; Key:JZRWCGZRTZMZEH-UHFFFAOYSA-N;

Thiamine (or thiamin) is vitamin B₁. It is a water-soluble vitamin of the B complex. Its phosphate derivatives take part in many cellular processes. Thiamine pyrophosphate (TPP) is a coenzyme in the catabolism of sugars and amino acids.

also it can be found in Food and Manufactured Dietary supplements also in Medications^[1]^[3] Foods that provide Thiamine include whole grains, Legume^[1]

Lack of thiamine causes beriberi.

References change

↑ ^1.0 ^1.1 ^1.2 "Thiamin Fact Sheets for Health Professionals". Office of Dietary Supplements. 11 February 2016. Archived from the original on 30 December 2016. Retrieved 30 December 2016.
↑ Royer-Morrot MJ, Zhiri A, Paille F, Royer RJ (1992). "Plasma thiamine concentrations after intramuscular and oral multiple dosage regimens in healthy men". European Journal of Clinical Pharmacology. 42 (2): 219–22. doi:10.1007/BF00278489. PMID 1618256. S2CID 19924442.
↑ "Thiamine: MedlinePlus Drug Information". medlineplus.gov. Retrieved 30 April 2018.

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[NIH2016-1] 1.0 ^1.1 ^1.2 "Thiamin Fact Sheets for Health Professionals". Office of Dietary Supplements. 11 February 2016. Archived from the original on 30 December 2016. Retrieved 30 December 2016.

[pmid1618256-2] Royer-Morrot MJ, Zhiri A, Paille F, Royer RJ (1992). "Plasma thiamine concentrations after intramuscular and oral multiple dosage regimens in healthy men". European Journal of Clinical Pharmacology. 42 (2): 219–22. doi:10.1007/BF00278489. PMID 1618256. S2CID 19924442.

[medline-3] "Thiamine: MedlinePlus Drug Information". medlineplus.gov. Retrieved 30 April 2018.

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[2]

[3]

Clinical data

Skeletal formula and ball-and-stick model of the cation in thiamine
Pronunciation	/ˈθaɪ.əmɪn/ THY-ə-min
Synonyms	Vitamin B₁, aneurine, thiamin
AHFS/Drugs.com	Monograph
License data	US DailyMed: Thiamine US FDA: Thiamine
Routes of administration	by mouth, IV, IM^[1]
Drug class	vitamin
ATC code	cation: A11DA01 (WHO)
Legal status
Legal status	US: OTC
Pharmacokinetic data
Bioavailability	3.7% to 5.3% ^{[medical citation needed]}
Elimination half-life	1.8d^[2]^{[better source needed]}
Identifiers
IUPAC name 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol
CAS Number	cation: 70-16-6^Y 67-03-8 (Cl^-.HCl) Cl^- salt: 59-43-8 ^Y
PubChem CID	cation: 1130
PubChem SID	Cl^- salt: 6042
DrugBank	cation: DB00152
ChemSpider	cation: 1098
UNII	cation: 4ABT0J945J Cl^- salt: X66NSO3N35^Y
KEGG	cation: C00378
ChEBI	cation: CHEBI:18385
ChEMBL	cation: ChEMBL1547
Chemical and physical data
Formula	C₁₂H₁₇N₄OS⁺
Molar mass	265.36 g·mol⁻¹
3D model (JSmol)	cation: Interactive image
SMILES cation: Cc2ncc(C[n+]1csc(CCO)c1C)c(N)n2
InChI cation: InChI=1S/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1^Y Key:JZRWCGZRTZMZEH-UHFFFAOYSA-N