The category is for articles and events specifically related to the decade of the 1500s which begins in the year 1500 and ends in the year 1509.
Note that 1500 is actually the last year of the 15th century; 1501 is the actual first year of the 16th century.
Wikimedia Commons has media related to 1500s
This category has the following 14 subcategories, out of 14 total.
Pages in category "1500s"
The following 2 pages are in this category, out of 2 total.