Ion channels are pore-forming proteins that help to establish and control the small voltage gradient across the plasma membrane of all living cells (see resting potential) by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells.
An ion channel is an integral membrane protein or more typically an assembly of several proteins.
- An Interview with Roderick MacKinnon Freeview video by the Vega Science Trust.
- The Voltage Sensor in Voltage-Dependent Ion Channels
- X-ray crystal structure of a potassium channel
- Neuromuscular Disease Center at Washington University
- Nobel Prize Press Release
- International Union of Pharmacologists, Ion channel compendium