Bioorthogonal chemistry
class of chemical reactions that can occur inside of living systems without interfering with native biochemical processes
The term bioorthogonal chemistry is about any chemical reaction that can happen inside of living systems without causing any problems with its native biochemical processes.[1][2][3] The term was created by Carolyn Bertozzi in 2003.[4][5] The idea of bioorthogonal reaction has caused a larger study of biomolecules such as glycans, proteins,[6] and lipids.[7]
References
change- ↑ Sletten, Ellen M.; Bertozzi, Carolyn R. (2009). "Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality". Angewandte Chemie International Edition. 48 (38): 6974–98. doi:10.1002/anie.200900942. PMC 2864149. PMID 19714693.
- ↑ Prescher, Jennifer A.; Dube, Danielle H.; Bertozzi, Carolyn R. (2004). "Chemical remodelling of cell surfaces in living animals". Nature. 430 (7002): 873–7. Bibcode:2004Natur.430..873P. doi:10.1038/nature02791. PMID 15318217. S2CID 4371934.
- ↑ Prescher, Jennifer A; Bertozzi, Carolyn R (2005). "Chemistry in living systems". Nature Chemical Biology. 1 (1): 13–21. doi:10.1038/nchembio0605-13. PMID 16407987. S2CID 40548615.
- ↑ Hang, Howard C.; Yu, Chong; Kato, Darryl L.; Bertozzi, Carolyn R. (2003-12-09). "A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation". Proceedings of the National Academy of Sciences. 100 (25): 14846–14851. Bibcode:2003PNAS..10014846H. doi:10.1073/pnas.2335201100. ISSN 0027-8424. PMC 299823. PMID 14657396.
- ↑ Sletten, Ellen M.; Bertozzi, Carolyn R. (2011). "From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions". Accounts of Chemical Research. 44 (9): 666–676. doi:10.1021/ar200148z. PMC 3184615. PMID 21838330.
- ↑ Plass, Tilman; Milles, Sigrid; Koehler, Christine; Schultz, Carsten; Lemke, Edward A. (2011). "Genetically Encoded Copper-Free Click Chemistry". Angewandte Chemie International Edition. 50 (17): 3878–3881. doi:10.1002/anie.201008178. PMC 3210829. PMID 21433234.
- ↑ Neef, Anne B.; Schultz, Carsten (2009). "Selective Fluorescence Labeling of Lipids in Living Cells". Angewandte Chemie International Edition. 48 (8): 1498–500. doi:10.1002/anie.200805507. PMID 19145623.
