Bryostatin

Bryostatins were first collected by JL Hartwell’s anticancer drug discovery group at the National Cancer Institute (NCI) by Jack Rudloe.

Bryostatin 1

Names
IUPAC name (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,20R,23R,25S)-25-Acetoxy-1,11,20-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl (2E,4E)-2,4-octadienoate
Identifiers
CAS Number	1: 83314-01-6
3D model (JSmol)	1: Interactive image
ChEBI	1: CHEBI:88353
ChEMBL	1: ChEMBL449158
ChemSpider	1: 27022418
DrugBank	1: DB11752
KEGG	1: C05149
PubChem CID	1: 5280757
UNII	1: 37O2X55Y9E
SMILES 1: CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)/C[C@H]2C[C@@H](OC(=O)[C@@H](CC[C@@H]3C[C@@H](C([C@@](O3)(C[C@@H]4C/C(=C/C(=O)OC)/C[C@@H](O4)/C=C/C([C@@]1(O2)O)(C)C)O)(C)C)OC(=O)C)O)[C@@H](C)O
Properties
Chemical formula	C47H68O17
Molar mass	905.04 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Further reading

• Proksch P, Edrada RA, Ebel R (July 2002). "Drugs from the seas - current status and microbiological implications". Applied Microbiology and Biotechnology. 59 (2–3): 125–34. doi:10.1007/s00253-002-1006-8. PMID 12111137. S2CID 29833324.

Other websites

• Kilham C. "The Importance of Drugs From the Sea". Fox News Health. Archived from the original on 25 April 2012.
• "Bryostatin 1". Aphios Corporation. Archived from the original on 2013-12-20. Retrieved 2013-12-19.
• "Bryostatin 2". Aphios Corporation. Archived from the original on 2012-11-12. Retrieved 2022-07-16.
• "Bryostatin 3". Aphios Corporation. Archived from the original on 2013-12-20. Retrieved 2022-07-16.