existence of shared ancestry between a pair of structures, or genes, in different taxa

A homologous[1] trait is any characteristic which is derived by evolution from a common ancestor. This is contrasted to analogous traits: similarities between organisms that were evolved separately.

Diagram of the skulls of a Monitor lizard and a Crocodile: homologous bones have the same colours.

The term existed before 1859, but got its modern meaning after Darwin established the idea of common descent.[2]p45 The pre-Darwinian naturalists Cuvier, Geoffroy and Richard Owen, also used the idea.

A homologous trait is often called a homologue (also spelled homolog). In genetics, the term "homologue" is used both to refer to a homologous protein, and to the gene (DNA sequence) encoding it.

Homology vs analogy change

According to Russell,[3] we owe to Richard Owen the first clear distinction between homologous and analogous organs. Owen's definitions were:

Analogue: a part or organ in one animal which has the same function as another part or organ in a different animal.
Homologue: the same organ in different animals under every variety of form and function.[4]

The distinction is made clear by examples such as the ear ossicles of mammals. These little bones have, in the course of several hundred million years of evolution, made their way from the gill covers of fish to the rear jaw bones of Synapsids to their present position in the ear of mammals. In the fossil record is evidence of this, and also in embryology.[5] As the embryo develops, the cartilage hardens to form bone. Later in development, tiny bone structures break loose from the jaw and migrate to the inner ear area.[6][7] The ear ossicles are homologous with the jaw bones and the gill covers, but not analogous.

This rather extraordinary story was first proposed in 1818 by Étienne Geoffroy Saint-Hilaire, who looked at fish and tried to discover the homologies of their bones with that of land vertebrates.[8]

Level of analysis change

The wings of pterosaurs (1), bats (2) and birds (3) are analogous as wings, but homologous as forearms.

A trait may be both homologous and analogous, depending on the level at which the trait is examined. For example, the wings of birds and bats are homologous as forearms in tetrapods. However, they are not homologous as wings, because the organ served as a forearm (not a wing) in the last common ancestor of tetrapods.[9]

By definition, any homologous trait defines a clade–a monophyletic taxon in which all the members have the trait (or have lost it secondarily); and all non-members lack it.[9]

Related terms change

Cladistic terms change

  • Homoplasy: evolved independently, but from the same ancestral structure.[10]
  • Plesiomorphy: present in a common ancestor but secondarily lost in some of its descendants.
  • Synapomorphy: present in an ancestor and all of its descendants.[9]

Gene sequences change

Conserved sequences of DNA, RNA and proteins can be used to decide homologies between organisms.

  • Orthology: genes or sequences of DNA which are similar because they came from a common ancestor. They were originally separated by a speciation event. Orthologs (orthologous genes) are genes in different species which originated by vertical descent from a single gene of the last common ancestor. The term "ortholog" was coined in 1970 by Walter Fitch.[11]
  • Paralogy: when a gene is duplicated to occupy two different places in the same genome, the two copies are paralogous. Paralogous genes often belong to the same species, but this is not necessary: for example, the haemoglobin gene of humans and the myoglobin gene of chimpanzees are paralogs. Paralogs typically have the same or similar function, but sometimes do not. At least one of the copies will be under less selection pressure, and may mutate and acquire a new function.
  • Xenology: Homologs resulting from horizontal gene transfer between two organisms. Xenologs can have different functions, if the new environment is vastly different for the horizontally moving gene. In general, though, xenologs typically have similar function in both organisms.[12]

Deep homology change

In evolutionary developmental biology, the concept of deep homology is used to describe cases where growth and differentiation are controlled by genetic mechanisms that are homologous and deeply conserved across a wide range of species.[13] Textbook examples common to metazoa include the homeotic genes that control differentiation along the body, and pax genes (especially PAX6) involved in the development of the eye and other sensory organs.

An algorithm identifies deeply homologous genetic modules in unicellular organisms, plants, and non-human animals based on phenotypes (such as traits and developmental defects). The technique aligns phenotypes across organisms based on the homology of genes involved in the phenotypes.[14][15]

References change

  1. Greek ομολογειν = 'to agree'
  2. Mayr, Ernst 1982. The growth of biological thought. Harvard.
  3. Russell E.S. 1916. Form and function: a contribution to the history of animal morphology. Murray, London. p108
  4. Owen, Richard 1843. Lectures on invertebrate animals. London. p374 & 379
  5. "Palaeos, the gill arches". Archived from the original on 2006-02-21. Retrieved 2010-10-19.
  6. Meng, Jin. 2003. The journey from jaw to ear. Biologist, 50, 154-158.
  7. Goodrich E.S. 1930. Studies on the structure and development of vertebrates. Macmillan, London.
  8. Saint-Hilaire, Étienne Geoffroy 1818. Philosopie anatomique. Paris.
  9. 9.0 9.1 9.2 Scotland R.W. 2010. "Deep homology: a view from systematics". BioEssays : news and reviews in molecular, cellular and developmental biology 32 (5): NA–ME. [1] [2]
  10. Butler A.B. 2009. Homology and homoplasty. In: Squire, Larry R. (ed) Encyclopedia of neuroscience, Academic Press. 1195–1199.
  11. Fitch W. (1970). "Distinguishing homologous from analogous proteins". Syst Zool. 19 (2): 99–113. doi:10.2307/2412448. JSTOR 2412448. PMID 5449325.
  12. NCBI Phylogenetics Factsheet
  13. Gilbert, Scott F. (2000). "Homologous pathways of development". Developmental biology (6th ed.). Sunderland, Mass: Sinauer Associates. ISBN 0-87893-243-7.
  14. Zimmer, Carl 2010. The search for genes leads to unexpected places, The New York Times, April 26, 2010.
  15. McGary K.L. et al 2010. Systematic discovery of nonobvious human disease models through orthologous phenotypes (2010). "Systematic discovery of nonobvious human disease models through orthologous phenotypes" (PDF). Proceedings of the National Academy of Sciences. 107 (14): 6544–9. Bibcode:2010PNAS..107.6544M. doi:10.1073/pnas.0910200107. PMC 2851946. PMID 20308572.{{cite journal}}: CS1 maint: numeric names: authors list (link)