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Eloise Gwendolyn Sanford (also known as Isabel Sanford; August 29, 1917 - July 9, 2004) was an American movie, television and stage actress. She acted in several notable sitcoms. She played Louise "Weezy" Jefferson in The Jeffersons (January 1975 - June 1985). She also had many movie roles.

Sanford was born in Harlem, New York. She died in Los Angeles from natural causes at age eighty six.