Jones won an Academy Award and a Golden Globe Award for her role as Bernadette Soubirous in The Song of Bernadette. She was also nominated for Academy Awards for her roles in: Since You Went Away, Love Letters, Duel in the Sun and Love Is a Many-Splendored Thing.
Jones married actor Robert Walker (1918–1951) in 1939. They had two sons, actor Robert Walker, Jr. (1940–2019) and Michael Walker (1941–2007). The couple divorced in 1945. She was married to movie producer David O. Selznick (1902–1965) from 1949 until his death. The couple had a daughter, Mary Jennifer Selznick (1954–1976). Jones was married to businessman Norton Simon (1907–1993) from 1971 until his death.
She died in Malibu, California on December 17, 2009 at the age of 90.