Klinefelter syndrome

Human disease
(Redirected from Klinefelter's syndrome)

Klinefelter syndrome, 47, XXY, or XXY syndrome is a genetic disorder where people have an extra number of X chromosomes.[1] People who have Klinefelter's Syndrome are often called "XXY Males", or "47, XXY Males".[2][dead link]

EffectsEdit

Males who have this condition are almost always infertile. This means that they cannot father babies.[3]

In other organismsEdit

Other males can have Klinefelter's Syndrome as well as humans. The mouse is one example.[4] Tortoiseshell or calico markings on male cats are an indicator of a similar syndrome. These cats are considered to be the model organism for Klinefelter syndrome, because the gene for a cat's tabby coat markings is found on the X chromosome. [5]

ReferencesEdit

  1. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 179. ISBN 0-7216-0187-1.CS1 maint: multiple names: authors list (link)
  2. Bock, Robert (1993). "Understanding Klinefelter Syndrome: A Guide for XXY Males and their Families" (HTML). NIH Pub. No. 93-3202. Office of Research Reporting, NICHD. Retrieved 2007-04-07.
  3. Denschlag, Dominik, MD; Clemens, Tempfer, MD; Kunze, Myriam, MD; Wolff, Gerhard, MD; Keck, Christoph, MD (October 2004). "Assisted reproductive techniques in patients with Klinefelter syndrome: A critical review". Fertility and Sterility. 82 (4): 775–779. doi:10.1016/j.fertnstert.2003.09.085. PMID 15482743.CS1 maint: date and year (link)
  4. Russell, Liane Brauch (9 June 1961). "Genetics of Mammalian Sex Chromosomes MOUSE STUDIES THROW LIGHT ON THE FUNCTIONS AND ON THE OCCASIONALLY ABERRANT BEHAVIOR OF SEX CHROMOSOMES". Science. 133 (3467): 1795–1803. doi:10.1126/science.133.3467.1795. line feed character in |title= at position 38 (help)CS1 maint: date and year (link)
  5. Centerwall WR, Benirschke K (1975). "An animal model for the XXY Klinefelter's syndrome in man: Tortoiseshell and calico male cats". American Journal of Veterinary Research. 36 (9): 1275–1280. PMID 1163864.

Other websitesEdit