Myelofibrosis
myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue
Primary myelofibrosis is a relatively rare bone marrow / blood cancer.[1] It is currently classified as a myeloproliferative neoplasm.[2][3]
Signs and symptoms
changeSymptoms include:
- Abdominal fullness related to an enlarged spleen (splenomegaly).
- Bone pain
- Bruising and easy bleeding due to inadequate numbers of platelets
- Cachexia (loss of appetite, weight loss, and fatigue)
- Enlargement of both the liver and spleen
- Fatigue
- Gout and high uric acid levels
- Increased susceptibility to infection, such as pneumonia
- Pallor and shortness of breath due to anemia
- In rarer cases, a raised red blood cell volume
- Cutaneous myelofibrosis is a rare skin condition characterized by dermal and subcutaneous nodules.[4]: 746
References
change- ↑ "Myelofibrosis Facts" (PDF). The Leukemia and Lymphoma Society. Retrieved 5 October 2014.
- ↑ myelofibrosis at Dorland's Medical Dictionary
- ↑ Tefferi, Ayalew (2014). "Primary myelofibrosis: 2014 update on diagnosis, risk-stratification, and management". American Journal of Hematology. 89 (9): 915–925. doi:10.1002/ajh.23703. ISSN 0361-8609. PMID 25124313. S2CID 26059182.
- ↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
