Natalya Vladimirovna Bochkareva was born in Gorky [now Nizhny Novgorod]. Both her parents died, her mother died at age 54 from complications after strokes and her father died at age 52 several years later. She has one sibling, younger sister Nadezhda Bochkareva.
In 2000 she graduated from Nizhny Novgorod Theatre School, and in 2002 from Moscow Art Theatre School.
She started her career in 1999 when played a small role in movie "Chinese service". Since 2006 she play main role Darya Bukina in TV series "Happy Together". It is an adaptation of series "Married ... With Children". She has been an actress with the Moscow Art Theatre since 2002.
Since 2010, she also is a television presenter.
On September 28, 2007 she married lawyer Nikolai Borisov. They has a two children, son Ivan Borisov (born on January 4, 2007) and daughter Maria Borisova (born on February 22, 2008). Natalya also has a stepdaughter, Alysa Borisova.