largest structure in the nucleus of eukaryotic cells

A nucleolus (plural: nucleoli) is the part of a eukaryotic cell where ribosomes are made. Seen under a microscope, the nucleolus is a dark spot inside the cell's nucleus. It is made up of dense RNA and proteins. Prokaryotic cells also have ribosomes, but they don't make as many as eukaryotes do, and there is no visible nucleotatius. There is usually more than one nucleolus in a eukaryote cell. The nucleolus is not bounded by a membrane.

The nucleolus is inside the cell nucleus

The nucleolus is made at a nucleolus organizer region (NOR), which is a chromosome region around which the nucleolus forms. Inside the nucleolus ribosomes are made. Ribosomes are molecular machines that synthesizes proteins. The ribosomes are exported through the nuclear envelope to the cytoplasm, where they do their work.[1]

Nucleoli play a role in the cell's response to stress. They also help in the assembly of signal recognition particles.[2] Malfunction of nucleoli can be the cause of several human diseases.[3]


  1. Cooper, Geoffrey M.; Hausman, Robert E. (2007). The Cell: a molecular approach (4th ed.). Sinauer Associates. pp. 371–9. ISBN 0878932208.
  2. Olsen, Mark OJ (2010). "Nucleolus: structure and function". eLS. doi:10.1002/9780470015902.a0005975.pub2. Retrieved October 17, 2014.
  3. Woods SJ, Hannan KM, Pearson RB, Hannan RD 2015. The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy. Biochimica et Biophysica Acta. 1849 (7): 821–9. [ ]