Sotalol

Sotalol
Clinical data
Trade names	Betapace, Sorine, Sotylize, others
AHFS/Drugs.com	Monograph
MedlinePlus	a693010
License data	US DailyMed: Sotalol;
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth
Drug class	Beta blocker
ATC code	C07AA07 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	90–100%
Metabolism	Not metabolized
Elimination half-life	12 hours
Excretion	Kidney ; Mammary gland (In lactating individuals)
Identifiers
	IUPAC name (RS)-N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide;
CAS Number	3930-20-9 ;
PubChem CID	5253;
IUPHAR/BPS	7297;
DrugBank	DB00489 ;
ChemSpider	5063 ;
UNII	A6D97U294I;
KEGG	D08525 ;
ChEMBL	ChEMBL471 ;
Chemical and physical data
Formula	C12H20N2O3S
Molar mass	272.36 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O=S(=O)(Nc1ccc(cc1)C(O)CNC(C)C)C;
	InChI InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 ; Key:ZBMZVLHSJCTVON-UHFFFAOYSA-N ;
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Sotalol (brand names Betapace, Betapace AF, Sorine, and Sotylize) belongs to a group of medicines called beta blockers. It is used to treat atrial fibrillation and other conditions that cause an irregular heartbeat (arrhythmia).^[3] It starts to work after about 4 hours, but it can take 2 to 3 days to fully take effect.^[3]

Related pages

Atropine

References

↑ "Sotalol Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 18 March 2019.
↑ ^2.0 ^2.1 ^2.2 ^2.3 U.S. Food and Drug Administration (July 2009). "Sotalol: Full Prescribing Information" (PDF). Retrieved 23 April 2015.
↑ ^3.0 ^3.1 "Sotalol: medicine to treat an irregular heartbeat". nhs.uk. 2018-08-29. Retrieved 2024-06-05.

[AHFS2019-1] "Sotalol Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 18 March 2019.

[fda2009-2] 2.0 ^2.1 ^2.2 ^2.3 U.S. Food and Drug Administration (July 2009). "Sotalol: Full Prescribing Information" (PDF). Retrieved 23 April 2015.

[:0-3] 3.0 ^3.1 "Sotalol: medicine to treat an irregular heartbeat". nhs.uk. 2018-08-29. Retrieved 2024-06-05.

[3]

[1]

[2]

Clinical data


Trade names	Betapace, Sorine, Sotylize, others^[1]
AHFS/Drugs.com	Monograph
MedlinePlus	a693010
License data	US DailyMed: Sotalol
Pregnancy category	AU: C
Routes of administration	By mouth
Drug class	Beta blocker
ATC code	C07AA07 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	90–100%^[2]
Metabolism	Not metabolized^[2]
Elimination half-life	12 hours^[2]
Excretion	Kidney Mammary gland (In lactating individuals)^[2]
Identifiers
IUPAC name (RS)-N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide
CAS Number	3930-20-9^Y
PubChem CID	5253
IUPHAR/BPS	7297
DrugBank	DB00489^Y
ChemSpider	5063^Y
UNII	A6D97U294I
KEGG	D08525^Y
ChEMBL	ChEMBL471^Y
Chemical and physical data
Formula	C₁₂H₂₀N₂O₃S
Molar mass	272.36 g·mol⁻¹
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES O=S(=O)(Nc1ccc(cc1)C(O)CNC(C)C)C
InChI InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3^Y Key:ZBMZVLHSJCTVON-UHFFFAOYSA-N^Y
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