Werner syndrome

Lethal autosomal recessive disorder

Werner syndrome (WS) (sometimes Werner's syndrome), also known as "adult progeria",[1] is a rare, autosomal recessive disorder[2] which causes the appearance of premature aging.[3]

Werner syndrome is named after the German scientist Otto Werner.

The odds of a baby being born with it are 1 in 100,000 live births.[4]


  1. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  2. Norbnop, Phatchara (August 2014). "ZRS 406A>G mutation in patients with tibial hypoplasia, polydactyly and triphalangeal first fingers". Journal of Human Genetics. 59 (8): 467–470. doi:10.1038/jhg.2014.50. PMID 24965254. S2CID 21552381.
  3. Gray MD, Shen JC, Kamath-Loeb AS, Blank A, Sopher BL, Martin GM, Oshima J, Loeb LA (1997). "The Werner syndrome protein is a DNA helicase". Nat. Genet. 17 (1): 100–3. doi:10.1038/ng0997-100. PMID 9288107. S2CID 20587915.
  4. Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J (2003). "Aging and genome maintenance: lessons from the mouse?". Science. 299 (5611): 1355–9. doi:10.1126/science.1079161. PMID 12610296. S2CID 840477.