Atenolol

beta blocker medication primarily used to treat high blood pressure

Atenolol (brand name: Tenormin) is a beta blocker medication which treats high blood pressure (hypertension), irregular heartbeats (arrhythmia) and angina.[2]

Atenolol
Clinical data
Trade namesTenormin, others
AHFS/Drugs.comMonograph
MedlinePlusa684031
License data
Pregnancy
category
  • AU: C
Routes of
administration
oral, Intravenous (IV)
Drug classSelective β1 receptor antagonist
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability40–50%
Protein binding6–16%[1]
MetabolismMinimal[1]
Onset of actionIV: <5 minutes[1]
Oral: <1 hour[1]
Elimination half-life6–7 hours[1]
Duration of action>24 hours[1]
ExcretionUrine (>85% IV, 50% oral)[1]
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.044.941 Edit this at Wikidata
Chemical and physical data
ChiralityRacemic mixture
  (verify)

History and culture

change

Atenolol was patented in 1969 and approved for medical use in 1975.[3] It is on the World Health Organization's List of Essential Medicines.[4] It is available as a generic medication.[5] In 2021, it was the 47th most commonly prescribed medication in the United States, with more than 14 million prescriptions.[6][7][8]

For people with high blood pressure, taking atenolol (or other beta blockers) helps prevent future heart disease, heart attacks and strokes. It can also be used to prevent chest pain caused by angina. Atenolol is sometimes prescribed to prevent migraines and help with anxiety.[2]

Action

change

Atenolol works by slowing down the heart rate, making it easier for the heart to pump blood around the body.[2]

change

References

change
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "DailyMed - TENORMIN- atenolol tablet". DailyMed. 30 June 2021. Archived from the original on 27 January 2022. Retrieved 20 November 2023.
  2. 2.0 2.1 2.2 "Atenolol: medicine for high blood pressure and angina". nhs.uk. 2022-04-06. Retrieved 2024-05-29.
  3. Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 9783527607495.
  4. World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  5. "Atenolol Monograph for Professionals". Drugs.com. AHFS. Archived from the original on 18 April 2019. Retrieved 23 December 2018.
  6. "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  7. "Atenolol - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
  8. Source Wikipedia