Bisoprolol

beta blocker family of medications of the β1 selective type.

Bisoprolol (brand names Cardicor, Congescor, Zebeta) is a beta blocker medication which treats high blood pressure (hypertension) and heart failure.[1]

Bisoprolol
Clinical data
Trade namesZebeta, Monocor, others
AHFS/Drugs.comMonograph
MedlinePlusa693024
Pregnancy
category
  • AU: C
Routes of
administration
By mouth
ATC code
Pharmacokinetic data
Bioavailability>90%
Protein binding30%[3]
Metabolism50% liver, CYP2D6, CYP3A4[2]
Elimination half-life10–12 hours[4]
ExcretionKidney, fecal (<2%)
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.108.941 Edit this at Wikidata
Chemical and physical data
ChiralityRacemic mixture
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Bisoprolol is also used to prevent chest pain caused by angina. It's also used to treat atrial fibrillation and other conditions that cause an irregular heartbeat.[1]

It works by slowing down the heart rate and making it easier for the heart to pump blood around the body.[1]

Bisoprolol was patented in 1976 and approved for medical use in 1986.[5] It was approved for medical use in the United States in 1992.[6]

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References

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  1. 1.0 1.1 1.2 "About bisoprolol". nhs.uk. 2022-01-06. Retrieved 2024-05-31.
  2. Horikiri Y, Suzuki T, Mizobe M (March 1998). "Pharmacokinetics and metabolism of bisoprolol enantiomers in humans". Journal of Pharmaceutical Sciences. 87 (3): 289–294. doi:10.1021/js970316d. PMID 9523980.
  3. Bühring KU, Sailer H, Faro HP, Leopold G, Pabst J, Garbe A (1986). "Pharmacokinetics and metabolism of bisoprolol-14C in three animal species and in humans". Journal of Cardiovascular Pharmacology. 8 (Suppl 11): S21–S28. doi:10.1097/00005344-198511001-00004. PMID 2439794. S2CID 38147937.
  4. Leopold G (1986). "Balanced pharmacokinetics and metabolism of bisoprolol". Journal of Cardiovascular Pharmacology. 8 (Suppl 11): S16–S20. doi:10.1097/00005344-198511001-00003. PMID 2439789. S2CID 25731558.
  5. Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 9783527607495. Archived from the original on 2017-09-08.
  6. "Bisoprolol Fumarate". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.