Bisoprolol
beta blocker family of medications of the β1 selective type.
Bisoprolol (brand names Cardicor, Congescor, Zebeta) is a beta blocker medication which treats high blood pressure (hypertension) and heart failure.[1]
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| Trade names | Zebeta, Monocor, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a693024 |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Bioavailability | >90% |
| Protein binding | 30%[3] |
| Metabolism | 50% liver, CYP2D6, CYP3A4[2] |
| Elimination half-life | 10–12 hours[4] |
| Excretion | Kidney, fecal (<2%) |
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| ECHA InfoCard | 100.108.941 |
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| Chirality | Racemic mixture |
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Bisoprolol is also used to prevent chest pain caused by angina. It's also used to treat atrial fibrillation and other conditions that cause an irregular heartbeat.[1]
It works by slowing down the heart rate and making it easier for the heart to pump blood around the body.[1]
Bisoprolol was patented in 1976 and approved for medical use in 1986.[5] It was approved for medical use in the United States in 1992.[6]
Related pages
changeReferences
change- ↑ 1.0 1.1 1.2 "About bisoprolol". nhs.uk. 2022-01-06. Retrieved 2024-05-31.
- ↑ Horikiri Y, Suzuki T, Mizobe M (March 1998). "Pharmacokinetics and metabolism of bisoprolol enantiomers in humans". Journal of Pharmaceutical Sciences. 87 (3): 289–294. doi:10.1021/js970316d. PMID 9523980.
- ↑ Bühring KU, Sailer H, Faro HP, Leopold G, Pabst J, Garbe A (1986). "Pharmacokinetics and metabolism of bisoprolol-14C in three animal species and in humans". Journal of Cardiovascular Pharmacology. 8 (Suppl 11): S21–S28. doi:10.1097/00005344-198511001-00004. PMID 2439794. S2CID 38147937.
- ↑ Leopold G (1986). "Balanced pharmacokinetics and metabolism of bisoprolol". Journal of Cardiovascular Pharmacology. 8 (Suppl 11): S16–S20. doi:10.1097/00005344-198511001-00003. PMID 2439789. S2CID 25731558.
- ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 9783527607495. Archived from the original on 2017-09-08.
- ↑ "Bisoprolol Fumarate". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.