Karl Barry Sharpless

American chemist and Nobel Laureate (born 1941)

Karl Barry Sharpless (born April 28, 1941) is an American chemist and Nobel Laureate in 2001 and 2022. He is known for his work on stereoselective reactions and click chemistry.[1]

Karl Barry Sharpless
Born (1941-04-28) April 28, 1941 (age 83)
NationalityUnited States
Alma materDartmouth College
Stanford University
Harvard University
Known forenantioselective synthesis, click chemistry
AwardsPriestley Medal (2019)
Nobel Prize in Chemistry (2001 and 2022)
Wolf Prize (2001)
Benjamin Franklin Medal (2001)
Rylander Award (2000)
Chemical Sciences Award (2000)
Chirality Medal (2000)
Rhone Poulenc Medal (2000)
Harvey Prize (1998)
Microbial Chemistry Medal (1997)
King Faisal International Prize (1995)
Cliff Hamilton Award (1995)
Tetrahedron Prize (1993)
Centenary Lectureship Medal (1993)
Arthur C. Cope Award (1992)
Scheele Award (1991)
Chemical Pioneer Award (1988)
Dr. Paul Janssen Prize (1986)
Allan Day Award (1985)
Scientific career
InstitutionsMassachusetts Institute of Technology
Stanford University
The Scripps Research Institute
ThesisStudies of the mechanism of action of 2,3-oxidosqualene-lanosterol cyclase: featuring enzymic cyclization of modified squalene oxides (1968)
Doctoral advisorEugene van Tamelen


  1. "2019 Priestley Medalist K. Barry Sharpless works magic in the world of molecules". Chemical & Engineering News. Retrieved 2019-04-08.