Labetalol

chemical compound

Labetalol (brand name Trandate,[1] Normodyne) is a beta blocker medication used to treat high blood pressure (hypertension), including high blood pressure in pregnancy.[1]

Labetalol
Clinical data
Pronunciation/ləˈbɛtəlɔːl/
Trade namesNormodyne, Trandate, others
AHFS/Drugs.comMonograph
MedlinePlusa685034
License data
Pregnancy
category
  • AU: C
Routes of
administration
By mouth, intravenous
ATC code
Pharmacokinetic data
Bioavailability25%
Protein binding50%
MetabolismLiver pass metabolism,
Elimination half-lifeTablet: 6–8 hours; IV: 5.5 hours
ExcretionExcreted in urine, not removed by hemodialysis
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.048.401 Edit this at Wikidata
Chemical and physical data
ChiralityRacemic mixture
  (verify)

Taking labetalol helps to prevent future heart disease, heart attacks and strokes in people with high blood pressure,[1] because they are at a higher risk. It can also be used to prevent chest pain caused by angina.[1]

Labetalol was patented in 1966 and came into medical use in 1977.[2] It is available as a generic medication.[3] In 2021, it was the 213th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[4][5][6]

Function

change

Labetalol works by slowing down the heart rate and making it easier for the heart to pump blood around the body.[1]

References

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  1. 1.0 1.1 1.2 1.3 1.4 "Common questions about labetalol". nhs.uk. 2022-03-08. Retrieved 2024-05-30.
  2. Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 463. ISBN 9783527607495.
  3. British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 147–148. ISBN 9780857113382.
  4. "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  5. "Labetalol - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
  6. Source Wikipedia