mTOR
protein-coding gene in the species Homo sapiens
mTOR is a protein, an enzyme which regulates cell growth, cell division, cell movement, cell survival, protein synthesis, autophagy, and transcription.[1] It is a protein that in humans is encoded by the MTOR gene.[2][3]
It has been given various names. It was originally called the 'mammalian target of rapamycin', but is also known as the 'mechanistic target of rapamycin' and 'FK506-binding protein 12-rapamycin-associated protein 1' (FRAP1).
The mTOR pathway is a central regulator of mammalian metabolism and physiology, with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain.[4]
References
change- ↑ Hay, Nissim; Sonenberg, Nahum (2004). "Upstream and downstream of mTOR". Genes & Development. 18 (16): 1926–45. doi:10.1101/gad.1212704. PMID 15314020.
- ↑ Brown, Eric J.; Albers, Mark W.; Bum Shin, Tae; Ichikawa, Kazuo; Keith, Curtis T.; Lane, William S.; Schreiber, Stuart L. (1994). "A mammalian protein targeted by G1-arresting rapamycin-receptor complex". Nature. 369 (6483): 756–8. Bibcode:1994Natur.369..756B. doi:10.1038/369756a0. PMID 8008069. S2CID 4359651.
- ↑ Moore, Paul A.; Rosen, Craig A.; Carter, Kenneth C. (1996). "Assignment of the human FKBP12-rapamycin-associated protein (FRAP) gene to chromosome 1p36 by fluorescence in situ hybridization". Genomics. 33 (2): 331–2. doi:10.1006/geno.1996.0206. PMID 8660990.
- ↑ Betz, Charles; Hall, Michael N. (2013). "Where is mTOR and what is it doing there?". Journal of Cell Biology. 203 (4): 563–74. doi:10.1083/jcb.201306041. PMC 3840941. PMID 24385483.