Metoprolol
medication of the selective β1 receptor blocker type
Metroprolol (brand names Lopressor and Toprol XL) is a beta blocker medication used to:[1]
- treat high blood pressure (hypertension)
- treat conditions that cause an irregular heartbeat (arrhythmia)
- help prevent future heart disease, heart attacks and strokes
- help prevent chest pain caused by angina
- prevent migraines
- reduce the symptoms of too much thyroid hormone in the body (thyrotoxicosis). Usually it will need to be taken together with other medicines to treat the symptoms
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| Pronunciation | /mɛˈtoʊproʊlɑːl/, /mɛtoʊˈproʊlɑːl/ |
| Trade names | Lopressor, Metolar XR, Toprol XL, others |
| Synonyms | Lopressor |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682864 |
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| Routes of administration | By mouth, intravenous |
| Drug class | Beta blocker |
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| Bioavailability | 50% (single dose)[2] 70% (repeated administration)[3] |
| Protein binding | 12% |
| Metabolism | Liver via CYP2D6, CYP3A4 |
| Elimination half-life | 3–7 hours |
| Excretion | Kidney |
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| ECHA InfoCard | 100.051.952 |
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| Chirality | Racemic mixture |
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Metoprolol was first made in 1969, patented in 1970, and approved for medical use in 1978.[4][5][6] It is on the World Health Organization's List of Essential Medicines.[7] It is available as a generic medication.[8] In 2021, it was the sixth most commonly prescribed medication in the United States, with more than 65 million prescriptions.[9][10][11]
Metoprolol is only available on prescription and it comes as tablets. It can also be given by injection, but this is usually done in hospital.[1]
Related pages
changeReferences
change- ↑ 1.0 1.1 "Metoprolol: medicine for high blood pressure (hypertension)". nhs.uk. 2022-03-15. Retrieved 2024-06-03.
- ↑ "Metolar 25/50 (metoprolol tartrate) tablet" (PDF). U.S. Food and Drug Administration (FDA). Archived (PDF) from the original on 3 March 2016. Retrieved 5 May 2015.
- ↑ Jasek W, ed. (2007). Austria-Codex (in German) (62nd ed.). Vienna: Österreichischer Apothekerverlag. pp. 916–919. ISBN 978-3852001814.
- ↑ "Lopressor: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 20 June 2023.
- ↑ Carlsson B, ed. (1997). Technological systems and industrial dynamics. Dordrecht: Kluwer Academic. p. 106. ISBN 978-0792399728. Archived from the original on 3 March 2017.
- ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 978-3527607495.
- ↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- ↑ "Metoprolol". The American Society of Health-System Pharmacists. Archived from the original on 12 March 2014. Retrieved 21 April 2014.
- ↑ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ↑ "Metoprolol – Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
- ↑ Source Wikipedia