O'Malley hosted the early 1990s children's game show Nickelodeon Guts. He starred in his own sitcom for NBC called The Mike O'Malley Show. He is best known for his role as Jimmy Hughes on Yes, Dear, a CBS series which aired from 2000 to 2006.
- "Mike O'Malley Biography (1969–)". Filmreference.com. October 31, 1969. Retrieved August 29, 2013.