Oestradiol, E2, is an oestrogen, a steroidal hormone secreted by the ovaries. It is a main female hormone. Oestradiol regulates female characteristics, the maturation of female sex organs and the oestrus and menstrual cycle. It stimulates the production of mammary glands.
The serum concentrations of oestradiol and other female hormones change during the menstrual cycle. During gestation there is a high serum concentrations of oestradiol, E3. During menopause, oestrone has the higher concentration.
Oestradiol also has some functions in males. Its serum concentration in men is < 35 pg/mL, level equivalent to that seen in post-menopausal women.
- Albright, Fuller; Smith, Patricia H. & Richardson Anna M. 1941. "Postmenopausal Osteoporosis: Its Clinical Features". JAMA. 116 (22): 2465–2474. doi:10.1001/jama.1941.02820220007002. Retrieved 20 November 2013.CS1 maint: multiple names: authors list (link)