Opioids are chemical substances that relieve pain. There are a wide range of natral and artificial opioids. They are used in hospitals to treat acute pain, as can occur after an operation. They can also be used to relieve pain, where treatment no longer makes sense, for example in certain cancer patients. Drugs that can relieve pain are broadly known as analgesics.
Different kinds of opioidsEdit
The term Opiate is sometimes used as a synonym. Most often it is used to refer to opium alkaloids, and semi-synthetic opioids.
So called endgenous opioiods, also called endorphins, are peptides produced by the human body. They are used to respond to stress, to suppress pain and hunger. They also interact with sex hormones and they can cause a states of Euphoria. Mammals produce them in the brain.
Opium alkaloids / OpiatesEdit
There are different alkaloids that naturally occur in opium. Opium is produced from Opium poppy. The most important ones are morphine, codeine and thebamine. Papaverine and noscarpine also occur in opium, but the way they work is different. Most of the time, they are therefore not counted as opiates.
Fully synthetic opioidsEdit
Addiction to opioidsEdit
Drug tolerance to opioids and other narcotics can develop with long use. This means that higher doses will be needed to keep the same effect. It also means that the body will eventually learn to operate normally with that amount of medication. When the user tries to stop taking these pain killers, withdrawal symptoms appear. These symptoms include restlessness, pain in the bones and muscles, insomnia, diarrhea, vomiting and involuntary leg movements.
If the addiction keeps on going, eventual permanent brain changes can appear.
- Hemmings, Hugh C.; Egan, Talmage D. (2013). Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application: Expert Consult - Online and Print. Elsevier Health Sciences. p. 253. ISBN 1437716792.
Opiate is the older term classically used in pharmacology to mean a drug derived from opium. Opioid, a more modern term, is used to designate all substances, both natural and synthetic, that bind to opioid receptors (including antagonists).
- McQuay H. 1999. Opioids in pain management: a review. The Lancet. 353(9171):2229-32 PMID 10393001