User:Mr. Ibrahem/Flunisolide
Clinical data | |
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Trade names | Aerospan, Aerobid, Nasalide, Nasarel, others |
Synonyms | 6α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione acetone cyclic 16,17-acetal |
AHFS/Drugs.com | Inahled: Monograph Nose: Monograph |
MedlinePlus | a681048 |
Routes of administration | Inhaled, in the nose |
Drug class | Corticosteroid[1][2] |
Pharmacokinetic data | |
Protein binding | 40% after inhalation |
Elimination half-life | 1.8 hours |
Identifiers | |
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Chemical and physical data | |
Formula | C24H31FO6 |
Molar mass | 434.50 g·mol−1 |
3D model (JSmol) | |
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Flunisolide, sold under the brand name Aerospan among others, is a steroid used for allergic rhinitis, asthma, and serous otitis media.[2][1] Intranasal steroids are the most effective medication for controlling of allergic rhinitis.[3] For asthma it is inhaled.[2]
When used in the nose common side effects include stinging, nose bleed, watery eyes, and upper respiratory tract infection.[1] When inhaled common symptoms include throat inflammation, runny nose, headache, and cough.[2] Other side effects may include loss of smell and adrenal suppression.[1] It has strong glucocorticoid and weak mineralocorticoid effects and works by decreasing inflammation.[1][2]
Flunisolide was patented in 1958 and approved for medical use in 1978.[4] It is on the World Health Organization's List of Essential Medicines as an alternative to budesonide.[5] In the United States 25 ml of solution to spray in the nose costs about 26 USD, while 60 doses for inhaling costs about 102 USD as of 2021.[6][7]
References
change- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "Flunisolide (EENT) Monograph for Professionals". Drugs.com. Archived from the original on 7 April 2016. Retrieved 11 December 2021.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "Flunisolide Monograph for Professionals". Drugs.com. Archived from the original on 15 April 2017. Retrieved 11 December 2021.
- ↑ Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, et al. (August 2008). "The diagnosis and management of rhinitis: an updated practice parameter". The Journal of Allergy and Clinical Immunology. 122 (2 Suppl): S1-84. doi:10.1016/j.jaci.2008.06.003. PMID 18662584.
- ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 486. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2020-10-19.
- ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ↑ "Flunisolide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 9 July 2020. Retrieved 12 December 2021.
- ↑ "Aerospan HFA Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 12 December 2021.