User:Mr. Ibrahem/Kidney agenesis
| Mr. Ibrahem/Kidney agenesis | |
|---|---|
| Other names | Renal agenesis |
| Video explanation | |
| Medical specialty | Nephrology |
| Symptoms | One kidney: None, high blood pressure, kidney failure[1] Both kidneys: Poor lung development, death shortly after birth[1] |
| Usual onset | Present at birth[1] |
| Types | Unilateral, bilateral[1] |
| Risk factors | Genetic mutation, diabetes or certain medication during pregnancy[1] |
| Diagnostic method | Medical imaging[2] |
| Differential diagnosis | Kidney dysplasia, surgical removal[2] |
| Treatment | Regular monitoring, treatment of high blood pressure[2] |
| Frequency | 1 in 2,000 (one kidney), 1 in 8,500 (both kidneys)[1] |
Kidney agenesis is a birth defect in which one or both kidneys fail to develop.[1] If only one kidney is involved, many people have no symptoms, though some develop high blood pressure and kidney failure.[1] If both kidneys are absent, the lungs will fail to develop and the child will die shortly after birth.[1]
A number of genetic mutations, such as in the RET proto-oncogene, can result in the condition.[1] Some cases run in families in either an autosomal dominant or autosomal recessive pattern.[1] Other risk factors include diabetes and the use of certain medication during pregnancy.[1] Diagnosis may occur before or after birth via medical imaging.[2]
Among those with a single kidney, regular monitoring of kidney function and blood pressure is recommended.[2] If high blood pressure is present ACE inhibitors may be recommended.[2] About 1 in 2,000 people have a single kidney affected and about 1 in 8,500 have both kidneys are affected.[1] Both kidneys are affected more often in males than females.[3]
References
change- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 "Renal agenesis | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Archived from the original on 18 March 2021. Retrieved 24 January 2021.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 "Solitary or Single-functioning Kidney | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Archived from the original on 9 January 2021. Retrieved 24 January 2021.
- ↑ "Renal Agenesis, Bilateral". NORD (National Organization for Rare Disorders). Archived from the original on 19 February 2017. Retrieved 24 January 2021.