He played Carlos the Jackal in the 2010 French-German biopic series Carlos. He won the César Award for Most Promising Actor in 2011 for the role and was nominated for a Golden Globe and Emmy Award for best actor.
He also played Larry, a CIA operative in the movie Zero Dark Thirty, Paz—a CIA assassin—in The Bourne Ultimatum, and Roberto Durán, a four-time world-champion boxer and member of the International Boxing Hall of Fame, in Hands of Stone.
Ramírez starred as Gianni Versace in the limited crime series The Assassination of Gianni Versace: American Crime Story. He also starred as Bodhi in the 2015 movie Point Break.
- The Late Show with Stephen Colbert (August 25, 2016). "Édgar Ramírez Salsa Dances onto Late Show Stage". Retrieved June 24, 2017 – via YouTube.
- César : Edgar Ramirez, espoir masculin, europe1.fr
- "Edgar Ramírez nominado a los premios César – Cine – EL UNIVERSAL". Archived from the original on July 25, 2011. Retrieved June 24, 2017.
- "Edgar Ramirez: Awards and". Television Academy. Retrieved August 31, 2015.