Chlorpromazine
chemical compound
Chlorpromazine is an antipsychotic drug. It is the oldest such drug. It was developed in 1950. It is typically used to treat Schizophrenia. It has also been used to treat bipolar disorder. It has been shown to help uncontrollable hiccups disappear. It is also used to help with nausea and vomiting.
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Trade names | Largactil, Thorazine, many others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682040 |
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Routes of administration | Oral (tablets and syrup available), rectal, IM, IV infusion |
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Pharmacokinetic data | |
Bioavailability | 10–80% (Oral; large interindividual variation)[1] |
Protein binding | 90–99%[1] |
Metabolism | Liver, mostly CYP2D6-mediated[1] |
Elimination half-life | 30 hours |
Excretion | Urine (43–65% in 24 hrs)[1] |
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ECHA InfoCard | 100.000.042 ![]() |
Chemical and physical data | |
Formula | C17H19ClN2S |
Molar mass | 318.86 g/mol (free base) 355.33 g/mol (hydrochloride) |
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