Chlorpromazine
chemical compound
Chlorpromazine, also known by its trade name Thorazine, is an antipsychotic drug. It is typically used to treat Schizophrenia. It has also been used to treat bipolar disorder. It has been shown to help uncontrollable hiccups disappear. It is also used to help with nausea and vomiting.[2] Chlorpromazine was developed in 1950, making it the oldest antipsychotic drug.[3]
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Trade names | Largactil, Thorazine, many others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682040 |
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Routes of administration | Oral (tablets and syrup available), rectal, IM, IV infusion |
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Bioavailability | 10–80% (Oral; large interindividual variation)[1] |
Protein binding | 90–99%[1] |
Metabolism | Liver, mostly CYP2D6-mediated[1] |
Elimination half-life | 30 hours |
Excretion | Urine (43–65% in 24 hrs)[1] |
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ECHA InfoCard | 100.000.042 |
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Formula | C17H19ClN2S |
Molar mass | 318.86 g/mol (free base) 355.33 g/mol (hydrochloride) |
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References
change- ↑ 1.0 1.1 1.2 1.3 "PRODUCT INFORMATION LARGACTIL" (PDF). TGA eBusiness Services. Sanofi Aventis Pty Ltd. 28 August 2012. Archived from the original on 30 March 2017. Retrieved 8 December 2013.
- ↑ "ChlorproMAZINE Monograph for Professionals". Drugs.com. Retrieved 2022-09-22.
- ↑ López-Muñoz, Francisco; Alamo, Cecilio; cuenca, Eduardo; Shen, Winston; Clervoy, Patrick; Rubio, Gabriel (2005-07-01). "History of the Discovery and Clinical Introduction of Chlorpromazine". Annals of Clinical Psychiatry. 17 (3): 113–135. doi:10.1080/10401230591002002. ISSN 1040-1237. PMID 16433053.