Mosaic (genetics)
In genetics, a mosaic (or mosaicism) means the presence of two different genotypes in an individual which developed from a single fertilized egg. As a result, the individual has two or more genetically different cell lines derived from a single zygote.[1]
Mosaicism may result from:
- Crossing-over during mitosis
- A gene mutation during development
- A chromosomal mutation during development
- X-inactivation: one X chromosome is randomly switched off in cells of a female mammal
The phenomenon was discovered by Curt Stern. In 1936, he demonstrated that recombination, normal in meiosis, can also take place in mitosis.[2] When it does, it results in somatic (body) mosaics. These are organisms which contain two or more genetically distinct types of tissue.[3]
Chimeras
changePeople who have mosaicism are often called chimeras but this is a mistake. A mosaic is originally from a single fertilised egg, whereas a chimaera comes from two fertilised eggs.
Other causes of two-tone appearances
changeThis is easiest to see with eye colours. When eye colours vary between the two eyes, or within one or both eyes, the condition is called heterochromia iridis (= 'different coloured iris'). It can have many different causes, both genetic and accidental. For example, David Bowie has the appearance of different eye colours due to an injury that caused one pupil to be permanently dilated.
On this page, only genetic mosaicism is discussed.
X-inactivation
changeThis is a controlled and natural developmental phenomenon in mammalian females. Females have two X chromosomes (and males have only one). The two X chromosomes in a female are rarely identical. They have the same genes, but at some loci (positions) they may have different alleles (versions of the same gene).
In the early embryo, each cell independently and randomly inactivates one copy of the X chromosome.[4] This inactivation lasts the lifetime of the cell, and all the descendants of the cell inactivate that same chromosome. X-inactivation is reversed in the female germline, so that all egg cells contain an active X chromosome.[5]
This phenomenon shows in the colouration of calico cats and tortoiseshell cats. These females are heterozygous for the X-linked colour genes: the genes for their coat colours are carried on the X chromosome. X-inactivation causes groups of cells to carry either one or the other X-chromosome in an active state.[6]
X-inactivation is an epigenetic change, a switching off of genes on one chromosome. It is not a change in the genotype.[7] Descendent cells of the embryo carry the same X-inactivation as the original cells. This may give rise to mild symptoms in female 'carriers' of X-linked genetic disorders.[8]
Mutations
changeMutations in body cells (somatic mutations) cause groups of cells to differ in their genetics.[9] Somatic mutation leading to mosaicism is common in the beginning and end stages of human life. Cancer research has shown that somatic mutations are responsible for most leukemia, lymphomas, and solid tumors.[10]
Related pages
changeReferences
change- ↑ The term has also been used for organisms with cells derived from more than one zygote.
- ↑ Stern C. 1936. Somatic crossing-over and segregation in Drosophila melanogaster. Genetics 21, 625–730.
- ↑ Stern, Curt 1968. Genetic mosaics in animals and man. pp27–129, in Stern C. Genetic mosaics and other essays. Harvard University Press, Cambridge, Massachusetts.
- ↑ Okamoto I (2004). "Epigenetic dynamics of imprinted X inactivation during early mouse development". Science. 303 (5658): 644–9. Bibcode:2004Sci...303..644O. doi:10.1126/science.1092727. PMID 14671313. S2CID 26326026.
- ↑ An account suitable for biology students is given in Carey, Nessa 2012. The epigenetics revolution, how modern biology is rewriting our understanding of genetics, disease and inheritance. Chapter 9, Generation X, p152 et seq. ISBN 978-183831347-7
- ↑ Klug, William S. et al 2012. Concepts of genetics. 10th ed, Pearson, p187 & 196. ISBN 0-321-79578-4
- ↑ Curt Stern described the set-up as "functional mosaicism". Stern 1968 p103
- ↑ Puck J; Willard, HF (1998). "X Inactivation in females with X-linked disease". N. Engl. J. Med. 338 (5): 325–8. doi:10.1056/NEJM199801293380511. PMID 9445416. Archived from the original on 2003-02-27. Retrieved 2012-05-13.
- ↑ De, S. 2011. Somatic mosaicism in healthy human tissues. Trends in Genetics. 27 (6): 217–223. [1]
- ↑ Jacobs, K. B.; et al. (2012). "Detectable clonal mosaicism and its relationship to aging and cancer". Nature Genetics. 44 (6): 651–U668. doi:10.1038/ng.2270. PMC 3372921. PMID 22561519.