MacIsaac at the 2009 premiere of The Last House on the Left
(m. 2010; div. 2015)
She has appeared in several plays including the 2006 play The Wild Duck in which she played Hedwig and was nominated for a Dora Mavor Moore Award for "Outstanding Performance by a Female in a Principal Role - Play". In 2009, she played Paige in a remake of the Wes Craven film The Last House on the Left. She also performed in three consecutive productions of Soulpepper Theatre Company's Our Town as Emily, beginning in 2006.
In a 2007 Entertainment Weekly article, she stated she has been inspired by Julia Roberts from the age of four and was self-described as "obsessed". She also stated she would like to perform alongside her in a film, particularly "a female version of Twins".
In late 2012, MacIsaac began a main role on the NBC comedy 1600 Penn as the president's eldest daughter, Becca. Brittany Snow was originally cast as Becca but because she did not physically resemble and fit in well with the other family members, Martha MacIsaac was cast. In a 2012 interview with the CBC Radio series Island Morning, she revealed that 1600 Penn was her last audition before she considered returning to Canada.
She is represented by the Agency for the Performing Arts.
|2003||This Time Around||Young Gabby Castellani||Film Debut|
|2004||Suburban Madness||Vivian Leigh Bacha|
|2005||Ice Princess||Mean Party Girl|
|2005||I Do, They Don't||Moira Lewellyn|
|2006||Night of Terror||Olivia Dunne|
|2007||In God's Country||Charlotte|
|2009||The Last House on the Left||Paige|
|2010||Faith, Fraud & Minimum Wage||Casey McCullen|
|2012||For a Good Time, Call...||Inmate|
|2012||Dead Before Dawn||Charlotte Baker|
|2013||Seasick Sailor||The Girl||Short film|
|2017||Battle of the Sexes||Jane Bartkowicz|
|2018||What Keeps You Alive||Sarah|
|1998–2000||Emily of New Moon||Emily Byrd Starr||46 episodes|
|2006||This Is Wonderland||Kristy Hausman|
|2006–2008||Di-Gata Defenders||Melosa (voice)||52 episodes|
|2007–2008||Magi-Nation||Edyn (voice)||26 episodes|
|2008||Friends and Heroes||Sarah (voice)||13 episodes|
|2010–2011||Greek||Dana Stockwell||9 episodes|
|2011||Marcy||Martha||Episode: "Marcy Does an Acting Class"|
Episode: "Marcy Does a Pool Party"
|2012||Spyburbia||Cissy (voice)||Episode: "Pilot"|
|2012||Family Guy||Patty (voice)||Episode: "Friends Without Benefits"|
|2012–2013||1600 Penn||Becca Gilchrist|
|2014–2015||The Pinkertons||Kate Warne||Main cast|
- "From New Moon to Superbad: P.E.I.'s MacIsaac goes Hollywood". cbc.ca. 2007-01-08. Retrieved 2013-02-11.
- Rainnie, Matt (2012-11-18). "Martha MacIsaac - 1600 Penn". cbc.ca. Retrieved 2013-02-11.
- Ouzounian, Richard (2005-07-22). "Ibsen's secrets told exceedingly well". Toronto Star. Retrieved 2013-02-11.
- Jones, Kenneth (2006-06-06). "Precious Stuff: Lord of the Rings Is Lord of Toronto's Dora Nominees, With 15 Nods". playbill.com. Archived from the original on 2013-04-11. Retrieved 2013-02-11.
- Garrett, Diane (2008-02-08). "Dillahunt joins cast of 'Last House'". variety.com. Retrieved 2013-02-11.
- Cole, Sally (2013-01-09). "Martha MacIsaac visits White House". theguardian.pe.ca. Retrieved 2013-02-11.
- Coulbourn, John (2006-02-03). "Soulpepper builds a beautiful 'Our Town'". jam.canoe.ca. Retrieved 2013-02-11.
- Bell, Carrie (2007-08-31). "Martha MacIsaac is dying to work with..." ew.com. Retrieved 2013-02-11.
- Andreeva, Nellie (2012-04-04). "NBC Pilot '1600 Penn' Recasts A Role". Deadline.com. Retrieved 2013-02-11.
- "Martha MacIsaac Makes "Minimum Wage"". seaandbescene.com. 2010-09-15. Retrieved 2013-02-11.