Molecular biology

Molecular biology is the study of biology at a molecular level. The field overlaps with other areas of biology and chemistry, particularly cell biology, genetics, biophysics and biochemistry.

Molecular biology chiefly concerns itself with understanding the interactions between the various systems of a cell, including the interrelationship of DNA, RNA and protein biosynthesis and learning how these interactions are regulated.

Relationship to other specialities

Schematic relationship between biochemistry, genetics and molecular biology

Researchers in molecular biology use specific techniques that are typical for molecular biology, but they combine these with techniques and ideas from genetics and biochemistry. There is no hard & fast line between these disciplines, as there once was. The following figure is a schematic that shows one possible view of the relationship between the fields:

• Biochemistry is the study of the chemical substances and vital processes occurring in living organisms.
• Genetics is the study of inheritance the effect of genetic differences on organisms.
• Molecular biology includes the study of the structure and function of all carbon-based macromolecules. This includes the chain of events from gene to protein: replication, transcription and translation. Much of the work in molecular biology is quantitative, and recently much work has been done at the interface of molecular biology and computer science in bioinformatics and computational biology. As of the early 2000s, the study of the genome has been amongst the most prominent sub-field of molecular biology.
• Cytology, which includes the appearance of cells and cell structures, microscopy, and the use of stains and tags to help distinguish organelles and processes.

Related pages

• DNA and chromosome structure
• Genome
• Cell
• Cell biology
• Cytology
• Transcription (genetics)
• Translation (genetics)

References

• Cohen S.N. Chang A.C.Y. Boyer H. & Heling R.B. 1973. Construction of biologically functional bacterial plasmids in vitro. PNAS 70, 3240–3244.
• Rodgers M. 1975. The Pandora's box congress. Rolling Stone 189, 37–77.

Other websites

Other reliable accounts

• Stanford Encyclopedia of Philosophy entry
• A brief history of molecular biology

Personal acounts of Nobel Prize winners

• Max Perutz Freeview Video interview with Max Perutz by the Vega Science Trust.
• Frederick Sanger Freeview Video Interview/Documentary by the Vega Science Trust.
• Christiane Nüsslein-Volhard Freeview interview by the Vega Science Trust.

Other

• DNA from the beginning
• Scientific American Magazine (April 2004) Evolution encoded
• DNA Interactive
• Nature Reviews Molecular Cell Biology (journal home)