Nephritis is often caused by infections, and toxins, but is most commonly caused by autoimmune disorders that affect the major organs like kidneys.
Nephritis can produce glomerular injury, by disturbing the glomerular structure with inflammatory cell proliferation. This can lead to reduced glomerular blood flow, leading to reduced urine output (oliguria) and retention of waste products (uremia). As a result, red blood cells may leak out of damaged glomeruli, causing blood to appear in the urine (hematuria).
- Keto Acids – Advances in Research and Application 2013 Edition p.220e
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- "uremia | accumulation in the blood of constituents normally eliminated in the urine that produces a severe toxic condition and usually occurs in severe kidney disease". www.merriam-webster.com. Retrieved 2015-06-14.
- "Hematuria (Blood in the Urine)". www.niddk.nih.gov. Archived from the original on 2016-06-24. Retrieved 2015-06-14.