Nifedipine

chemical compound

Nifedipine (brand names: Adalat, Adipine, Coracten, Fortipine, Nifedipress) is a calcium channel blocker medicine used to treat high blood pressure (hypertension).[3]

Nifedipine
Clinical data
Trade namesAdalat, Procardia, others
AHFS/Drugs.comMonograph
MedlinePlusa684028
License data
Pregnancy
category
Routes of
administration
By mouth, topical
Drug classCalcium channel blocker (dihydropyridine)[2]
ATC code
Pharmacokinetic data
Bioavailability45-56%
Protein binding92-98%
MetabolismGastrointestinal, Liver
Elimination half-life2 hours
ExcretionKidneys: >50%, bile duct: 5-15%
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.040.529 Edit this at Wikidata
  (verify)

In people with high blood pressure, taking nifedipine helps to prevent future heart disease, heart attacks and strokes.[3] Nifedipine is also used to prevent chest pain caused by angina. Occasionally, it is used to treat Raynaud's phenomenon and chilblains.[3]

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References

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  1. "Nifedipine Pregnancy and Breastfeeding Warnings". Archived from the original on 21 December 2015. Retrieved 25 December 2015.
  2. "Nifedipine". The American Society of Health-System Pharmacists. Archived from the original on 8 August 2018. Retrieved 17 September 2019.
  3. 3.0 3.1 3.2 "About nifedipine". nhs.uk. 2022-02-25. Retrieved 2024-05-30.