Paul Lawrence Modrich (born June 13, 1946) is an American biochemist. He is known for his research on DNA mismatch repair. He received the Nobel Prize in Chemistry 2015, together with Aziz Sancar and Tomas Lindahl.
Paul L. Modrich
Paul Lawrence Modrich
June 13, 1946
Raton, New Mexico, U.S.
|Alma mater||MIT, Stanford University (PhD)|
|Known for||Clarification of cellular resistance to carcinogens|
Nobel Prize in Chemistry (2015)
|Fields||DNA mismatch repair|
|Website||Paul L. Modrich|
He was born on June 13, 1946, in Raton, New Mexico to Laurence and Margaret Modrich. He has a younger brother Dave. His father was a biology teacher and coach for basketball, football and tennis at Raton High School where he graduated in 1964.
He works primarily on strand-directed mismatch repair. His lab demonstrated how DNA mismatch repair serves as a copyeditor to prevent errors from DNA polymerase. Matthew Meselson previously proposed the existence of recognition of mismatches. Modrich performed biochemical experiments to study mismatch repair in E. coli. They later searched for proteins associated with mismatch repair in humans.
- Broad, William J. (October 7, 2015). "Nobel Prize in Chemistry Awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar for DNA Studies". The New York Times. ISSN 0362-4331. Retrieved December 13, 2015.
- Staff (October 7, 2015). "THE NOBEL PRIZE IN CHEMISTRY 2015 - DNA repair – providing chemical stability for life" (PDF). Nobel Prize. Retrieved December 13, 2015.
- Su, SS; Modrich, P (July 1986). "Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs". Proceedings of the National Academy of Sciences of the United States of America. 83 (14): 5057–61. Bibcode:1986PNAS...83.5057S. doi:10.1073/pnas.83.14.5057. PMC 323889. PMID 3014530.
- "Paul Modrich Awarded 2015 Nobel Prize in Chemistry". HHMI. HHMI. October 7, 2015. Retrieved December 13, 2015.