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Amino acid metabolism intermediates
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Amino acid
metabolism
metabolic intermediates
K
→
acetyl-CoA
lysine
→
Saccharopine
Allysine
α-Aminoadipic acid
2-Oxoadipic acid
Glutaryl-CoA
Glutaconyl-CoA
Crotonyl-CoA
β-Hydroxybutyryl-CoA
leucine
→
β-Hydroxy β-methylbutyric acid
β-Hydroxy β-methylbutyryl-CoA
Isovaleryl-CoA
α-Ketoisocaproic acid
β-Ketoisocaproic acid
β-Ketoisocaproyl-CoA
β-Leucine
β-Methylcrotonyl-CoA
β-Methylglutaconyl-CoA
β-Hydroxy β-methylglutaryl-CoA
tryptophan
→
alanine
→
N
′-Formylkynurenine
Kynurenine
Anthranilic acid
3-Hydroxykynurenine
3-Hydroxyanthranilic acid
2-Amino-3-carboxymuconic semialdehyde
2-Aminomuconic semialdehyde
2-Aminomuconic acid
Glutaryl-CoA
G
G→
pyruvate
→
citrate
glycine
→
serine
→
3-Phosphoglyceric acid
glycine
→
creatine
:
Glycocyamine
Phosphocreatine
Creatinine
G→
glutamate
→
α-ketoglutarate
histidine
→
Urocanic acid
Imidazol-4-one-5-propionic acid
Formiminoglutamic acid
Glutamate-1-semialdehyde
proline
→
1-Pyrroline-5-carboxylic acid
arginine
→
Agmatine
Ornithine
Citrulline
Cadaverine
Putrescine
other
cysteine
+
glutamate
→
glutathione
:
γ-Glutamylcysteine
G→
propionyl-CoA
→
succinyl-CoA
valine
→
α-Ketoisovaleric acid
Isobutyryl-CoA
Methacrylyl-CoA
3-Hydroxyisobutyryl-CoA
3-Hydroxyisobutyric acid
2-Methyl-3-oxopropanoic acid
isoleucine
→
2,3-Dihydroxy-3-methylpentanoic acid
2-Methylbutyryl-CoA
Tiglyl-CoA
2-Methylacetoacetyl-CoA
methionine
→
generation of homocysteine
:
S
-Adenosyl methionine
S
-Adenosyl-
L
-homocysteine
Homocysteine
conversion to cysteine
:
Cystathionine
α-Ketobutyric acid
+
Cysteine
threonine
→
α-Ketobutyric acid
propionyl-CoA
→
Methylmalonyl-CoA
G→
fumarate
phenylalanine
→
tyrosine
→
4-Hydroxyphenylpyruvic acid
Homogentisic acid
4-Maleylacetoacetic acid
G→
oxaloacetate
see
urea cycle
Other
Cysteine metabolism
Cysteine sulfinic acid