Tiotropium bromide
Tiotropium bromide (brand names Braltus, Spiriva, Spiriva Respimat in the UK[1]) is a drug which belongs to a group of medicines called anticholinergic bronchodilators. It is used as a bronchodilator. It helps people with COPD and asthma[2][1] as preventative drug, known as a preventive inhaler - it is a long-acting drug and usually only needs to be taken once a day.[1]
 HandiHaler, which can be used for breathing tiotropium bromide. | |
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| Trade names | Spiriva, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a604018 |
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| Routes of administration | By mouth, inhalation by mouth |
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| Bioavailability | 19.5% (inhalation) |
| Metabolism | Liver 25% (CYP2D6, CYP3A4) |
| Elimination half-life | 5–6 days |
| Excretion | Kidney |
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| ECHA InfoCard | 100.234.575 |
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It is used when people have trouble breathing to help them breathe better, such as easing coughing, wheezing and feeling breathless in asthma. It is used by breathing it through the mouth.[2] Its effects last for 24 hours.[2][12]
Some side effects can happen from using it, such as having a dry mouth, runny nose, headache, or having problems with breathing. There are also serious side effects that could happen, such as angioedema and bronchospasms. It has not been proven to be bad to use while pregnant, but this has not been studied very much.[13] In 2020, there were more than 5 million prescriptions for tiotropium bromide in the United States.[14]
References
change- ↑ 1.0 1.1 1.2 "About tiotropium inhalers". nhs.uk. 2023-11-02. Retrieved 2024-06-02.
- ↑ 2.0 2.1 2.2 Committee, Joint Formulary (2018-09-21). BNF 76 September 2018-March 2019. Pharmaceutical Press. ISBN 978-0-85711-338-2.
- ↑ Cite error: The named reference
Preg2019was used but no text was provided for refs named (see the help page). - ↑ 4.0 4.1 "AusPAR: Tiotropium bromide". Therapeutic Goods Administration (TGA). 29 November 2016. Archived from the original on 1 October 2021. Retrieved 30 September 2021.
- ↑ https://www.ebs.tga.gov.au/servlet/xmlmillr6?dbid=ebs/PublicHTML/pdfStore.nsf&docid=E07D6674E971FA91CA258752004228AF&agid=(PrintDetailsPublic)&actionid=1 [dead link]
- ↑ "Tiotropium bromide". Therapeutic Goods Administration (TGA). Archived from the original on 1 October 2021. Retrieved 30 September 2021.
- ↑ "Spiriva 18 microgram inhalation powder, hard capsule - Summary of Product Characteristics (SmPC)". (emc). 15 January 2019. Archived from the original on 1 October 2021. Retrieved 30 September 2021.
- ↑ "Spiriva Respimat 2.5 microgram, inhalation solution - Summary of Product Characteristics (SmPC)". (emc). 14 January 2021. Archived from the original on 1 October 2021. Retrieved 30 September 2021.
- ↑ "Tiogiva 18 microgram, inhalation powder, hard capsule - Summary of Product Characteristics (SmPC)". (emc). 2 June 2021. Archived from the original on 1 October 2021. Retrieved 30 September 2021.
- ↑ "Spiriva Handihaler- tiotropium bromide capsule". DailyMed. Archived from the original on 1 October 2021. Retrieved 30 September 2021.
- ↑ "Spiriva Respimat- tiotropium bromide inhalation spray spray, metered". DailyMed. Archived from the original on 1 October 2021. Retrieved 30 September 2021.
- ↑ "Tiotropium Monograph for Professionals". Drugs.com. Retrieved 2022-11-15.
- ↑ "Tiotropium Use During Pregnancy". Drugs.com. Retrieved 2022-11-15.
- ↑ "The Top 300 of 2020". clincalc.com. Retrieved 2022-11-15.