Benzylpiperazine

Benzylpiperazine
Clinical data
Routes of; administration	Oral, intravenous, insufflation
ATC code	none;
Legal status
Legal status	AU: S9 (Prohibited substance) ; CA: Schedule III ; DE: Anlage II (Authorized trade only, not prescriptible) ; NZ: Class C ; UK: POM (Prescription only) ; US: Schedule I ;
Pharmacokinetic data
Bioavailability	Unknown
Metabolism	Hepatic
Elimination half-life	5.5 Hours
Excretion	Renal
Identifiers
	IUPAC name 1-Benzylpiperazine;
CAS Number	2759-28-6 ;
PubChem CID	75994;
ChemSpider	68493 ;
UNII	3UG152ZU0E;
ChEBI	CHEBI:83537 ;
ChEMBL	ChEMBL113600 ;
ECHA InfoCard	100.018.567
Chemical and physical data
Formula	C11H16N2
Molar mass	176.258 g/mol
3D model (JSmol)	Interactive image;
	SMILES C1(CN2CCNCC2)=CC=CC=C1;
	InChI InChI=1S/C11H16N2/c1-2-4-11(5-3-1)10-13-8-6-12-7-9-13/h1-5,12H,6-10H2 ; Key:IQXXEPZFOOTTBA-UHFFFAOYSA-N ;
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Benzylpiperazine, commonly referred to as BZP is an recreational drug. It is also available with trade names such as "A2", "Frenzy" and "Nemesis",^[4] It is a stimulant and may cause Euphoria. People believe it works in a way similar to MDMA. The effects produced by BZP are comparable to those produced by amphetamine. Side-effects include acute psychosis, problems with the kidneys Adverse effects have been reported following its use including acute psychosis and seizures. It does not appear to be very addictive and no deaths have been reported following taking BZP once. There have been at least two deaths which resulted from the combination of BZP and MDMA. Its sale is banned in a few countries, including the United States, Australia, New Zealand and in parts of Europe.^[5] However, its legal status is currently less restrictive in some other countries such as Ireland and Canada. The European Union is currently changing its laws to regulate this substance more.

References

↑ "Controlled Drugs and Substances Act : Legislative history · Schedule III · Sections 2 to 32: Methylphenidate to BZP and TFMPP. Isomer Design". Retrieved 2012-11-24.^{[permanent dead link]}
↑ "Amending Schedule III to the Controlled Drugs and Substances Act (BZP and TFMPP)". Canada Gazette. Retrieved 2012-11-24.
↑ Antia U, Lee HS, Kydd RR, Tingle MD, Russell BR (April 2009). "Pharmacokinetics of 'party pill' drug N-benzylpiperazine (BZP) in healthy human participants". Forensic Sci. Int. 186 (1–3): 63–7. doi:10.1016/j.forsciint.2009.01.015. PMID 19261399.
↑ David McCandless (2005-12-13). "Clubbers snap up new legal high". The Guardian. Retrieved 2008-05-26.
↑ Alexandra Topping (2007-06-18). "Legal dance drug faces ban amid fears over side-effects". The Guardian. Retrieved 2008-05-26.

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[1] "Controlled Drugs and Substances Act : Legislative history · Schedule III · Sections 2 to 32: Methylphenidate to BZP and TFMPP. Isomer Design". Retrieved 2012-11-24.^{[permanent dead link]}

[2] "Amending Schedule III to the Controlled Drugs and Substances Act (BZP and TFMPP)". Canada Gazette. Retrieved 2012-11-24.

[3] Antia U, Lee HS, Kydd RR, Tingle MD, Russell BR (April 2009). "Pharmacokinetics of 'party pill' drug N-benzylpiperazine (BZP) in healthy human participants". Forensic Sci. Int. 186 (1–3): 63–7. doi:10.1016/j.forsciint.2009.01.015. PMID 19261399.

[BLTC-4] David McCandless (2005-12-13). "Clubbers snap up new legal high". The Guardian. Retrieved 2008-05-26.

[5] Alexandra Topping (2007-06-18). "Legal dance drug faces ban amid fears over side-effects". The Guardian. Retrieved 2008-05-26.

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Clinical data


Routes of administration	Oral, intravenous, insufflation
ATC code	none
Legal status
Legal status	AU: S9 (Prohibited substance) CA: Schedule III ^[1]^[2] DE: Anlage II (Authorized trade only, not prescriptible) NZ: Class C UK: POM (Prescription only) US: Schedule I
Pharmacokinetic data
Bioavailability	Unknown
Metabolism	Hepatic
Elimination half-life	5.5 Hours^[3]
Excretion	Renal
Identifiers
IUPAC name 1-Benzylpiperazine
CAS Number	2759-28-6^Y
PubChem CID	75994
ChemSpider	68493^Y
UNII	3UG152ZU0E
ChEBI	CHEBI:83537^N
ChEMBL	ChEMBL113600^Y
ECHA InfoCard	100.018.567
Chemical and physical data
Formula	C₁₁H₁₆N₂
Molar mass	176.258 g/mol
3D model (JSmol)	Interactive image
SMILES C1(CN2CCNCC2)=CC=CC=C1
InChI InChI=1S/C11H16N2/c1-2-4-11(5-3-1)10-13-8-6-12-7-9-13/h1-5,12H,6-10H2^Y Key:IQXXEPZFOOTTBA-UHFFFAOYSA-N^Y
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