Latent autoimmune diabetes
The English used in this article or section may not be easy for everybody to understand. (February 2012)
Latent autoimmune diabetes in adults (LADA) is similar to both type 1 diabetes and type 2 diabetes. Like type 1 diabetes, LADA is an autoimmune disease of the pancreas. This means the body's immune system attacks the cells in the pancreas that are supposed to make insulin. But LADA is also like type 2 diabetes, because it causes insulin resistance. This means that insulin does not work as well as it should in a person's body.
LADA and diabetesEdit
Differences between LADA and type 1 diabetesEdit
The biggest difference between LADA and type 1 diabetes is that LADA has a gradual onset (it comes on slowly).
Also, people with type 1 diabetes cannot make insulin. But if they are given a shot of insulin, the insulin works and does its job in their bodies. But in people with LADA, even if they are given insulin, the insulin may not work as well as it should.
Differences between LADA and type 2 diabetesEdit
Most people with LADA become insulin-dependent (have to inject insulin) within 3-15 years. This is very different from type 2 diabetes. Only 20%-30% of type 2 diabetics end up being insulin-dependent.
Another difference is that type 2 diabetes can happen to anyone at any age. But LADA does not affect children or teenagers[source?]. It usually affects people age 35 and older, but can affect anyone between 20-29 years of age.
With LADA, the pancreas cannot make insulin because the immune system is attacking its insulin-making cells. This does not happen in type 2 diabetes.
Diagnosis and treatmentEdit
People with LADA are sometimes misdiagnosed (diagnosed incorrectly) as having type 1 or type 2 diabetes. A special blood test can prove what kind of diabetes a person has. The test looks for an antibody that only diabetics with LADA have. It is called a GAD antibody test.
People with LADA usually control their diabetes using very similar methods and changes of lifestyle to type 2 diabetes: eating right, exercising and oral medications; weight loss is optional. Unlike Type 2 diabetics who might never need to inject insulin, however, the LADA patients become insulin dependent within several years.
Genes and antibodiesEdit
- "Autoimmune Diabetes Not Requiring Insulin at Diagnosis (Latent Autoimmune Diabetes of the Adult)". Diabetes Care. Retrieved 20 February 2016.
- LADA/Insulin Resistance (Report). Diabetes Health. Retrieved April 10, 2010.
- "Prediction of Type I Diabetes". UCDenver.edu. Retrieved Mar 23, 2016.
- "Type 1.5 Diabetes". Bottom Line Health. Retrieved Mar 23, 2016.
- LADA: A Little Known Type of Diabetes (Report). Pharmacy Times. Retrieved January 27, 2010.
- "LADA". Action LADA. Retrieved Apr 22, 2010.
- "Latent Autoimmune Diabetes of Adults". American Diabetes Association. Retrieved Jan 26, 2010.
- "What is LADA". Retrieved 22 November 2009.
- Dunn, J. P.; Perkins, J. M.; Jagasia, S. M. (2008). "Latent Autoimmune Diabetes in Adults and Pregnancy: Foretelling the Future". Clinical Diabetes. 26: 44. doi:10.2337/diaclin.26.1.44.
- Family History and LADA (Report). PubMed. Retrieved Jan 23, 2010.
- "Latent Autoimmune Diabetes of Adults". JCEM. Retrieved Mar 23, 2016.
- "What is LADA". Blood Sugar 101. Retrieved November 22, 2009.