Saint-Marc (Haitian Creole: Sen Mak) is a commune in the western part of Haiti in the Artibonite department, it is located in , in 2003 it had a population of 160,181 inhabitants, being the second most populous city in Haiti after Gonaïves, Port-au-Prince and Cap-Haïtien.
The port of this city is the most preferred for the entry of goods to Haiti, due to the congested port of Port-au-Prince.
- Jean Baptiste Point du Sable (before 1750): First permanent non-Indigenous settler of what would later become Chicago, Illinois, and is recognized as the "Founder of Chicago."
- Pierre Toussaint (d. 1853): Former slave, famous hairdresser and philanthropist in New York, and Catholic venerable.
- Nissage Saget (1810–1880): Tenth president of Haiti. The first Haitian president to serve out his term of office (1869–1874) and retire voluntarily.
- Marc Louis Bazin (1932–2010): Minister of Finance and Economy, fourth Prime Minister of Haiti and provisional President of Haiti.
- Garcelle Beauvais (1966–): Haitian-American actress, television personality, author, and former fashion model.