Sirtuin
enzyme
Sirtuin or Sir2 proteins are a class of enzymes that are important in cell biology.[1][2][3][4][5]
Sirtuins regulate important biological pathways in bacteria, archaea and eukaryotes. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2',[6] the gene responsible for cellular regulation in yeast.
Sirtuins influence many cellular processes like ageing, transcription, apoptosis, inflammation and stress resistance,[7] as well as energy efficiency and alertness during low-calorie situations.[8] Sirtuins can also control circadian clocks and mitochondrial biogenesis.
ReferencesEdit
- ↑ North BJ & Verdin E. 2004. "Sirtuins: Sir2-related NAD-dependent protein deacetylases". Genome Biology. 5 (5): 224. doi:10.1186/gb-2004-5-5-224. PMC 416462. PMID 15128440. Vancouver style error: punctuation (help)
- ↑ Yamamoto H; Schoonjans K & Auwerx J. 2007. "Sirtuin functions in health and disease". Mol. Endocrinol. 21 (8): 1745–55. doi:10.1210/me.2007-0079. PMID 17456799. Vancouver style error: punctuation (help)
- ↑ Du J et a2. "Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase". Science. 334 (6057): 806–809. doi:10.1126/science.1207861. PMC 3217313. PMID 22076378. Vancouver style error: punctuation (help)
- ↑ Jiang H et a2. "SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine". Nature. 496 (7443): 110–113. doi:10.1038/nature12038. PMC 3635073. PMID 23552949. Vancouver style error: punctuation (help)
- ↑ Rack J.G.M. et al 2015. "Identification of a class of protein ADP-ribosylating sirtuins in microbial pathogens". Molecular Cell. 59 (2): 309–320. doi:10.1016/j.molcel.2015.06.013. ISSN 1097-4164. PMC 4518038. PMID 26166706.
- ↑ EntrezGene 23410 [1]
- ↑ Preyat N & Leo O. 2013. "Sirtuin deacylases: a molecular link between metabolism and immunity". J. Leuk. Biol. 93 (5): 669–680. doi:10.1189/jlb.1112557. PMID 23325925. Vancouver style error: punctuation (help)
- ↑ Satoh A. et al 2010. "SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus". Journal of Neuroscience. 30 (30): 10220–32. doi:10.1523/JNEUROSCI.1385-10.2010. PMC 2922851. PMID 20668205.