|Centuries:||13th century – 14th century – 15th century|
|Decades:||1310s 1320s 1330s – 1340s – 1350s 1360s 1370s|
|Years:||1345 1346 1347 – 1348 – 1349 1350 1351|
- April 7 – Charles University is founded in Prague.
- June 24 – Black Death outbreak in full swing in Melcombe Regis (modern-day Weymouth, Dorset in England)
- July 6 – Papal bull of Pope Clement VI protecting Jews against popular aggression during the Black Death epidemic.
- Beginning of Black Death epidemic in central and western Europe
- End of the reign of Emperor Komyo of Japan, second of the Northern Ashikaga Pretenders
- Start of the reign of Emperor Sukō, third of the Northern Ashikaga Pretenders
- May – Black Death reaches England
- Edward III of England creates the first English order of chivalry, the Order of the Garter
- Pskov gains independence from the Novgorod Republic with the treaty of Bolotovo; Pskov Republic formed.
- Black Death in Cairo.
- Estimation: Hangzhou in Yuan Dynasty China becomes the largest city of the world, taking the lead from Cairo, capital of Mamluk Egypt.
- Truce between England and France until 1532.
- Gonville Hall, the forerunner of Gonville and Caius College, Cambridge was founded.
- February 2 – Narymunt, Prince of Pinsk
- December 2 – Emperor Hanazono, Emperor of Japan (born 1297)
- Laura, beloved of Petrarch (born 1310)
- John de Stratford, Archbishop of Canterbury
- Ambrogio Lorenzetti, Sienese painter (born 1290)
- Pietro Lorenzetti, Sienese painter (born 1280)
- Andrea Pisano, Italian sculptor and architect (born 1270)