|Centuries:||14th century – 15th century – 16th century|
|Decades:||1460s 1470s 1480s – 1490s – 1500s 1510s 1520s|
|Years:||1493 1494 1495 – 1496 – 1497 1498 1499|
- January 3 – Leonardo da Vinci unsuccessfully tests a flying machine.
- March 10 – Christopher Columbus leaves Hispaniola for Spain, ending his second visit to the Western Hemisphere.
- July – Spanish forces under Gonzalo Hernandez de Cordoba capture Atella after a siege. Among the prisoners is the French viceroy of Naples, the Comte de Montpensier. Ferrante II is restored to the throne of Naples.
- Jesus College (University of Cambridge) founded.
- March 28 – Mary Tudor, queen of Louis XII of France (died 1533)
- May 12 – King Gustav I of Sweden (died 1560)
- October 20 – Claude, Duke of Guise, French soldier (died 1550)
- François Bonivard, Swiss historian (died 1570)
- Edward Fox, English churchman (died 1538)
- Richard Maitland, Scottish poet (died 1586)
- Clément Marot, French poet (died 1544)
- Anthony St Leger, Lord Deputy of Ireland (died 1559)
- Menno Simons, Dutch religious leader (died 1561)
- Henry Somerset, 2nd Earl of Worcester (died 1549)